© 2018 OCNI

Adrián Cortés PhD Senior Postdoctoral Statistician 

Adrián received his PhD in 2014 from The University of Queensland in Brisbane, Australia. The focus of his dissertation was on the genetics of ankylosing spondylitis, a common form of inflammatory disease. Before that he studied Mathematics (BSc) and Bioinformatics (MSc) at The University of British Columbia in Vancouver, Canada. He is originally from Cuernavaca, Mexico. He joined the Fugger (WIMM) and McVean (WTCHG) groups in June of 2014 where he aims to continue researching the genetics of immune-mediate diseases and to develop statistical methods for the joint analysis of genetic and functional genomics datasets for better understanding the effects of susceptibility variants in the predisposition to disease.

Education and Training

BSc Mathematics, University of British Columbia 2006

MSc Bioinformatics, University of British Columbia 2010

Ph.D. Human Genetics, University of Queensland 2014; Supervisor: Matthew Brown 

 

Selected Publications 

 

Cortes A, Dendrou C, Motyer A, Jostins L, Vukcevic D, et al. Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank. Nature Genetics, 2017.

 

Dendrou CA, Cortes A, Shipman L, Evans HG, Attfield KE, et al.  Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Science Translational Medicine, 2016.

 

Parkes M, Cortes A, van Heel DA & Brown MA. Genetic insights into common pathways and complex relationships among immune mediated diseases. Nature Reviews Genetics, 2013.

 

Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nature Genetics, 2013.

 

Cortes A, Field J, Glazov EA, Hadler J, Stankovich J & Brown MA. Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes. Human Molecular Genetics, 2013.

 

Other Publications

Leo PJ, Madeleine MM, Wang S, Schwartz SM, Newell F, et al. Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study. PLoS Genetics, 2017.

 

H Huang, M Fang, L Jostins, MM Umićević, G Boucher, et al. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature, 2017.

Roberts AM, Vecellio M, Cortes A, Knight JC, Cohen CJ, Wordsworth BP. Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis. Genes and immunity, 2017.

 

Roberts AR, Appleton LH, Cortes A, Vecellio M, Lau J, et al. ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations. Proceedings of the National Academy of Sciences, 2017.

 

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, et al. Genome-wide genetic data on ~500,000 UK Biobank participants. bioRxiv, 2017.

 

Kaur G, Gras S, Mobbs JI, Vivian JP, Cortes A, et al. Structural and regulatory diversity shape HLA-C protein expression levels. Nature Communications, 2017.

 

Thomas GP, Willner D, Robinson PC, Cortes A, Duan R, et al. Genetic diagnostic profiling in axial spondyloarthritis: a real world study. Clinical and experimental rheumatology, 2017.

Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, et al. Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature genetics, 2016.

 

Roberts AR, Vecellio M, Chen L, Ridley A, Cortes A, et al. An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation. Annals of the rheumatic diseases, 2016.