© 2018 OCNI

Christiane Desel PhD Senior Postdoctoral Fellow

Christiane’s research is focussed on identification of disease causing pathways and the role of MS susceptibility variants with an emphasis on non-immune cell mediated mechanisms. She is also involved in international collaborations to explore novel cutting edge technology in order to elucidate disease progression and neuroinflammation.

 

Christiane has a long-standing interest in cellular immunology, especially on how adaptive immune responses are generated upon activation of innate immune cells. She obtained her PhD at the Max-Planck Institute for Infection Biology with Prof. S.H.E. Kaufmann in Berlin, Germany where she analyzed vaccine-induced antigen-specific T cell responses in the lung. She then worked as a Postdoctoral Researcher with Prof. R. Lang at the Institute for Clinical Microbiology, Immunology and Hygiene at the University Hospital Erlangen, Germany. There she characterized glycolipid-mediated activation of the C-type lectin receptor Mincle, for which she was awarded a young investigators ELAN grant from the University Hospital Erlangen in 2013. Christiane joined the Fugger lab in 2014 and is now working as a senior postdoc.

 Publications 

 

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Dendrou CA, Cortes A, Shipman L, Evans HG, Attfield KE, Jostins L, Barber T, Kaur G, Kuttikkatte SB, Leach OA, Desel C, Faergeman SL, Cheeseman J, Neville MJ, Sawcer S, Compston A, Johnson AR, Everett C, Bell JI, Karpe F, Ultsch M, Eigenbrot C, McVean G, Fugger L. (2016)  Science Translational Medicine 

 

The Mincle-activating Adjuvant TDB Induces MyD88-dependent Th1 and Th17 Responses through IL-1R signalling. Christiane Desel*, Kerstin Werninghaus, Manuel Ritter, Katrin Jozefowski, Jens Wenzel, Norman Russkamp, Ulrike Schleicher, Dennis Christensen, Stefan Wirtz, Carsten Kirschning, Else Marie Agger, Clarissa Prazeres da Costa and Roland Lang*. PlosOne (2013) DOI: 10.1371/journal.pone.0053531. *corresponding author

 

Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: findings, implications and open questions. Roland Lang, Hanne Schoenen and Christiane Desel. Immunobiology (2011) Nov;216(11):1184-91.

 

Recombinant BCGΔureC hly+ induces superior protection over parental BCG by stimulating a balanced combination of type 1 and type 17 cytokine responses. Christiane Desel, Anca Dorhoi, Silke Bandermann, Leander Grode, Bernd Eisele and Stefan H.E. Kaufmann. Journal of Infectious Diseases (2011) Nov 15;204(10):1573-84.

 

Control of innate inflammation by CARD9 determines outcome of tuberculosis. Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J and Kaufmann SH. Journal of Experimental Medicine (2010) Apr 12;207(4):777-92.

 

Immunogenicity and protective efficacy of prime-boost regimens with recombinant ΔureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis. Elma Z Tchilian*, Christiane Desel*, Emily K Forbes, Silke Bandermann, Clare Sander, Helen McShane, Adrian VS Hill and Stefan H.E. Kaufmann. Infection and Immunity (2009) Feb;77(2):622-31. *equal contribution

 

The biological effects of syngeneic and allogeneic cytokine-expressing prophylactic whole cell vaccines and the influence of irradiation in a murine melanoma model. Labarthe MC, Halanek N, Birchall L, Russell N, Desel C, Todryk S, Peters MJ, Lucas A, Falkenberg FW, Dalgleish AG, Whelan M and Ward SJ. Cancer Immunology Immunotherapy (2006) Mar;55(3):277-88.