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Selected Publications

1.     Dendrou CA, McVean G, Fugger L. (2016) Neuroinflammation - using big data to inform clinical practice. Nature Reviews Neurology


2.     Dendrou CA, Cortes A, Shipman L, Evans HG, Attfield KE, Jostins L, Barber T, Kaur G, Kuttikkatte SB, Leach OA, Desel C, Faergeman SL, Cheeseman J, Neville MJ, Sawcer S, Compston A, Johnson AR, Everett C, Bell JI, Karpe F, Ultsch M, Eigenbrot C, McVean G, Fugger L. (2016) Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Science Translational Medicine


3.     Dendrou CA, Fugger L, Friese MA. (2015) Immunopathology of multiple sclerosis. Nature Reviews Immunology


4.     Friese, M. A., Schattling, B. and Fugger, L. (2014) Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. Nature Reviews Neurology, 10:225-238.


5.     Dendrou, C. A., Bell, J. I. and Fugger, L. (2013) Weighing in on autoimmune disease: Big data tip the scale. Nature Medicine, 19:138-139.


6.     Fugger, L., McVean, G. and Bell, J. I. (2012) Genomewide association studies and common disease-realizing clinical utility. The New England Journal of Medicine, 367:2370-2371.


7.     Gregory, A. P., Dendrou, C. A., et al., Fugger, L. (2012) TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature, 23:508-511. 


8.     Fugger, L., Friese, M. and Bell, J. (2009) From genes to function: The next challenge in the genetics of multiple sclerosis. Nature Reviews Immunology, 9:408-417. 


9.     Harkiolaki, M., Holmes, S., et al., Fugger, L. (2009) A mechanism for T-cell-mediated autoimmune disease resulting from highly specific but low affinity cross-reactivity to common microbial peptides. Immunity, 30:348-357.


10.  Friese, M., Jakobsen, K., et al., Fugger, L. (2008) Opposing effects of HLA class I molecules in tuning autoreactive CD8+T-cells in multiple sclerosis. Nature Medicine, 14:1227-1235. 


11.  Tzartos, J., Friese, M., et al. Fugger, L. (2008) Interleukin-17 production in CNS-infiltrating T-cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathology, 172:146-155.


12.  Friese, M., Craner, M., et al., Fugger, L. (2007) Acid-sensing ion channel 1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Medicine, 12:1483-1489. 


13.  Gregersen, J. W., Kranc, K., et al., Fugger L. (2006) Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature, 443:574-577.


14.  Jones, E.Y.*, Fugger, L.*, Strominger, J.L., et al., (2006) MHC class II proteins and disease: a structural perspective. Nature Reviews Immunology, 6:271-282. *Shared senior authorship.


15.  Lang, H., Jacobsen, H., et al., Fugger, L. (2002) A functional and structural basis for T cell receptor cross-reactivity in multiple sclerosis. Nature Immunology, 3:940-943.

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