Lise Torp Jensen PhD Senior Scientist

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After obtaining my PhD in Medical Microbiology and Immunology from Aarhus University, I joined Prof Lars Fugger’s group, where I have been mainly involved in the development and characterisation of transgenic mouse models for various autoimmune diseases. I am now employed at the Department of Clinical Medicine, Aarhus University Hospital where I pursue my research interest in understanding the interplay between genetic and environmental variables in chronic inflammatory diseases. Another research focus is to understand how a small population of orexin-producing neurons is involved in the immune-mediated sleep disorder narcolepsy, and in behaviour in general.Christiane’s research is focussed on identification of disease causing pathways and the role of MS susceptibility variants with an emphasis on non-immune cell mediated mechanisms. She is also involved in international collaborations to explore novel cutting edge technology in order to elucidate disease progression and neuroinflammation.



Fugger, L., Jensen, L. T., & Rossjohn, J. (2020). Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases. Cell, 181(1), 63–80. 


Faergeman, S. L., Evans, H., Attfield, K. E., Desel, C., Kuttikkatte, S. B., Sommerlund, M., Jensen, L. T., Frokiaer, J., Friese, M. A., Matthews, P. M., Luchtenborg, C., Brügger, B., Oturai, A. B., Dendrou, C. A., & Fugger, L. (2020). A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Cell death & disease, 11(5), 303


Dagkonaki, A., Avloniti, M., Evangelidou, M., Papazian, I., Kanistras, I., Tseveleki, V., Lampros, F., Tselios, T., Jensen, L. T., Möbius, W., Ruhwedel, T., Androutsou, M. E., Matsoukas, J., Anagnostouli, M., Lassmann, H., & Probert, L. (2020). Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions. Frontiers in immunology, 11, 575451. 


Kaur, G., Gras, S., Mobbs, J. I., Vivian, J. P., Cortes, A., Barber, T., Kuttikkatte, S. B., Jensen, L. T., Attfield, K. E., Dendrou, C. A., Carrington, M., McVean, G., Purcell, A. W., Rossjohn, J., & Fugger, L. (2017). Structural and regulatory diversity shape HLA-C protein expression levels. Nature communications, 8, 15924


González, J. A., Jensen, L. T., Iordanidou, P., Strom, M., Fugger, L., & Burdakov, D. (2016). Inhibitory Interplay between Orexin Neurons and Eating. Current biology : CB, 26(18), 2486–2491


González, J. A., Jensen, L. T., Fugger, L., & Burdakov, D. (2012). Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area. The European journal of neuroscience, 35(9), 1426–1432


Du Pré, M. F., Kozijn, A. E., van Berkel, L. A., ter Borg, M. N., Lindenbergh-Kortleve, D., Jensen, L. T., Kooy-Winkelaar, Y., Koning, F., Boon, L., Nieuwenhuis, E. E., Sollid, L. M., Fugger, L., & Samsom, J. N. (2011). Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells. Gastroenterology, 141(2), 610–620


Karnani, M. M., Apergis-Schoute, J., Adamantidis, A., Jensen, L. T., de Lecea, L., Fugger, L., & Burdakov, D. (2011). Activation of central orexin/hypocretin neurons by dietary amino acids. Neuron, 72(4), 616–629


Venner, A., Karnani, M. M., Gonzalez, J. A., Jensen, L. T., Fugger, L., & Burdakov, D. (2011). Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels. The Journal of physiology, 589(Pt 23), 5701–5708


Karnani, M. M., Venner, A., Jensen, L. T., Fugger, L., & Burdakov, D. (2011). Direct and indirect control of orexin/hypocretin neurons by glycine receptors. The Journal of physiology, 589(Pt 3), 639–651


Harkiolaki, M., Holmes, S. L., Svendsen, P., Gregersen, J. W., Jensen, L. T., McMahon, R., Friese, M. A., van Boxel, G., Etzensperger, R., Tzartos, J. S., Kranc, K., Sainsbury, S., Harlos, K., Mellins, E. D., Palace, J., Esiri, M. M., van der Merwe, P. A., Jones, E. Y., & Fugger, L. (2009). T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides. Immunity, 30(3), 348–357


González, J. A., Jensen, L. T., Doyle, S. E., Miranda-Anaya, M., Menaker, M., Fugger, L., Bayliss, D. A., & Burdakov, D. (2009). Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons. The European journal of neuroscience, 30(1), 57–64


Friese, M. A., Jakobsen, K. B., Friis, L., Etzensperger, R., Craner, M. J., McMahon, R. M., Jensen, L. T., Huygelen, V., Jones, E. Y., Bell, J. I., & Fugger, L. (2008). Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nature medicine, 14(11), 1227–1235


Williams, R. H., Alexopoulos, H., Jensen, L. T., Fugger, L., & Burdakov, D. (2008). Adaptive sugar sensors in hypothalamic feeding circuits. Proceedings of the National Academy of Sciences of the United States of America, 105(33), 11975–11980


González, J. A., Jensen, L. T., Fugger, L., & Burdakov, D. (2008). Metabolism-independent sugar sensing in central orexin neurons. Diabetes, 57(10), 2569–2576


Williams, R. H., Jensen, L. T., Verkhratsky, A., Fugger, L., & Burdakov, D. (2007). Control of hypothalamic orexin neurons by acid and CO2. Proceedings of the National Academy of Sciences of the United States of America, 104(25), 10685–10690


Friese, M. A., Jensen, L. T., Willcox, N., & Fugger, L. (2006). Humanized mouse models for organ-specific autoimmune diseases. Current opinion in immunology, 18(6), 704–709


Burdakov, D., Jensen, L. T., Alexopoulos, H., Williams, R. H., Fearon, I. M., O'Kelly, I., Gerasimenko, O., Fugger, L., & Verkhratsky, A. (2006). Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron, 50(5), 711–722


Stengaard-Pedersen, K., Thiel, S., Gadjeva, M., Møller-Kristensen, M., Sørensen, R., Jensen, L. T., Sjøholm, A. G., Fugger, L., & Jensenius, J. C. (2003). Inherited deficiency of mannan-binding lectin-associated serine protease 2. The New England journal of medicine, 349(6), 554–560


Jensen, L. T., Thorsen, P., Møller, B., Birkelund, S., & Christiansen, G. (1998). Antigenic and genomic homogeneity of successive Mycoplasma hominis isolates. Journal of medical microbiology, 47(8), 659–666


Huniche, B. S., Jensen, L. T., Birkelund, S., & Christiansen, G. (1998). Mycoplasma contamination of Chlamydia pneumoniae isolates. Scandinavian journal of infectious diseases, 30(2), 181–187


Boesen, T., Emmersen, J., Jensen, L. T., Ladefoged, S. A., Thorsen, P., Birkelund, S., & Christiansen, G. (1998). The Mycoplasma hominis vaa gene displays a mosaic gene structure. Molecular microbiology, 29(1), 97–110


Christiansen, G., Jensen, L. T., Boesen, T., Emmersen, J., Ladefoged, S. A., Schiøtz, L. K., & Birkelund, S. (1997). Molecular biology of Mycoplasma. Wiener klinische Wochenschrift, 109(14-15), 557–561


Ladefoged, S. A., Jensen, L. T., Brock, B., Birkelund, S., & Christiansen, G. (1996). Analysis of 0.5-kilobase-pair repeats in the Mycoplasma hominis lmp gene system and identification of gene products. Journal of bacteriology, 178(10), 2775–2784


Jensen, L. T., Ladefoged, S., Birkelund, S., & Christiansen, G. (1995). Selection of Mycoplasma hominis PG21 deletion mutants by cultivation in the presence of monoclonal antibody 552. Infection and immunity, 63(9), 3336–3347


Ladefoged, S. A., Birkelund, S., Hauge, S., Brock, B., Jensen, L. T., & Christiansen, G. (1995). A 135-kilodalton surface antigen of Mycoplasma hominis PG21 contains multiple directly repeated sequences. Infection and immunity, 63(1), 212–223