Lise Torp Jensen PhD Senior Scientist
After obtaining my PhD in Medical Microbiology and Immunology from Aarhus University, I joined Prof Lars Fugger’s group, where I have been mainly involved in the development and characterisation of transgenic mouse models for various autoimmune diseases. I am now employed at the Department of Clinical Medicine, Aarhus University Hospital where I pursue my research interest in understanding the interplay between genetic and environmental variables in chronic inflammatory diseases. Another research focus is to understand how a small population of orexin-producing neurons is involved in the immune-mediated sleep disorder narcolepsy, and in behaviour in general.Christiane’s research is focussed on identification of disease causing pathways and the role of MS susceptibility variants with an emphasis on non-immune cell mediated mechanisms. She is also involved in international collaborations to explore novel cutting edge technology in order to elucidate disease progression and neuroinflammation.
Publications
Fugger, L., Jensen, L. T., & Rossjohn, J. (2020). Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases. Cell, 181(1), 63–80.
Faergeman, S. L., Evans, H., Attfield, K. E., Desel, C., Kuttikkatte, S. B., Sommerlund, M., Jensen, L. T., Frokiaer, J., Friese, M. A., Matthews, P. M., Luchtenborg, C., Brügger, B., Oturai, A. B., Dendrou, C. A., & Fugger, L. (2020). A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Cell death & disease, 11(5), 303
Dagkonaki, A., Avloniti, M., Evangelidou, M., Papazian, I., Kanistras, I., Tseveleki, V., Lampros, F., Tselios, T., Jensen, L. T., Möbius, W., Ruhwedel, T., Androutsou, M. E., Matsoukas, J., Anagnostouli, M., Lassmann, H., & Probert, L. (2020). Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions. Frontiers in immunology, 11, 575451.
Kaur, G., Gras, S., Mobbs, J. I., Vivian, J. P., Cortes, A., Barber, T., Kuttikkatte, S. B., Jensen, L. T., Attfield, K. E., Dendrou, C. A., Carrington, M., McVean, G., Purcell, A. W., Rossjohn, J., & Fugger, L. (2017). Structural and regulatory diversity shape HLA-C protein expression levels. Nature communications, 8, 15924
González, J. A., Jensen, L. T., Iordanidou, P., Strom, M., Fugger, L., & Burdakov, D. (2016). Inhibitory Interplay between Orexin Neurons and Eating. Current biology : CB, 26(18), 2486–2491
González, J. A., Jensen, L. T., Fugger, L., & Burdakov, D. (2012). Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area. The European journal of neuroscience, 35(9), 1426–1432
Du Pré, M. F., Kozijn, A. E., van Berkel, L. A., ter Borg, M. N., Lindenbergh-Kortleve, D., Jensen, L. T., Kooy-Winkelaar, Y., Koning, F., Boon, L., Nieuwenhuis, E. E., Sollid, L. M., Fugger, L., & Samsom, J. N. (2011). Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells. Gastroenterology, 141(2), 610–620
Karnani, M. M., Apergis-Schoute, J., Adamantidis, A., Jensen, L. T., de Lecea, L., Fugger, L., & Burdakov, D. (2011). Activation of central orexin/hypocretin neurons by dietary amino acids. Neuron, 72(4), 616–629
Venner, A., Karnani, M. M., Gonzalez, J. A., Jensen, L. T., Fugger, L., & Burdakov, D. (2011). Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels. The Journal of physiology, 589(Pt 23), 5701–5708
Karnani, M. M., Venner, A., Jensen, L. T., Fugger, L., & Burdakov, D. (2011). Direct and indirect control of orexin/hypocretin neurons by glycine receptors. The Journal of physiology, 589(Pt 3), 639–651
Harkiolaki, M., Holmes, S. L., Svendsen, P., Gregersen, J. W., Jensen, L. T., McMahon, R., Friese, M. A., van Boxel, G., Etzensperger, R., Tzartos, J. S., Kranc, K., Sainsbury, S., Harlos, K., Mellins, E. D., Palace, J., Esiri, M. M., van der Merwe, P. A., Jones, E. Y., & Fugger, L. (2009). T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides. Immunity, 30(3), 348–357
González, J. A., Jensen, L. T., Doyle, S. E., Miranda-Anaya, M., Menaker, M., Fugger, L., Bayliss, D. A., & Burdakov, D. (2009). Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons. The European journal of neuroscience, 30(1), 57–64
Friese, M. A., Jakobsen, K. B., Friis, L., Etzensperger, R., Craner, M. J., McMahon, R. M., Jensen, L. T., Huygelen, V., Jones, E. Y., Bell, J. I., & Fugger, L. (2008). Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nature medicine, 14(11), 1227–1235
Williams, R. H., Alexopoulos, H., Jensen, L. T., Fugger, L., & Burdakov, D. (2008). Adaptive sugar sensors in hypothalamic feeding circuits. Proceedings of the National Academy of Sciences of the United States of America, 105(33), 11975–11980
González, J. A., Jensen, L. T., Fugger, L., & Burdakov, D. (2008). Metabolism-independent sugar sensing in central orexin neurons. Diabetes, 57(10), 2569–2576
Williams, R. H., Jensen, L. T., Verkhratsky, A., Fugger, L., & Burdakov, D. (2007). Control of hypothalamic orexin neurons by acid and CO2. Proceedings of the National Academy of Sciences of the United States of America, 104(25), 10685–10690
Friese, M. A., Jensen, L. T., Willcox, N., & Fugger, L. (2006). Humanized mouse models for organ-specific autoimmune diseases. Current opinion in immunology, 18(6), 704–709
Burdakov, D., Jensen, L. T., Alexopoulos, H., Williams, R. H., Fearon, I. M., O'Kelly, I., Gerasimenko, O., Fugger, L., & Verkhratsky, A. (2006). Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron, 50(5), 711–722
Stengaard-Pedersen, K., Thiel, S., Gadjeva, M., Møller-Kristensen, M., Sørensen, R., Jensen, L. T., Sjøholm, A. G., Fugger, L., & Jensenius, J. C. (2003). Inherited deficiency of mannan-binding lectin-associated serine protease 2. The New England journal of medicine, 349(6), 554–560
Jensen, L. T., Thorsen, P., Møller, B., Birkelund, S., & Christiansen, G. (1998). Antigenic and genomic homogeneity of successive Mycoplasma hominis isolates. Journal of medical microbiology, 47(8), 659–666
Huniche, B. S., Jensen, L. T., Birkelund, S., & Christiansen, G. (1998). Mycoplasma contamination of Chlamydia pneumoniae isolates. Scandinavian journal of infectious diseases, 30(2), 181–187
Boesen, T., Emmersen, J., Jensen, L. T., Ladefoged, S. A., Thorsen, P., Birkelund, S., & Christiansen, G. (1998). The Mycoplasma hominis vaa gene displays a mosaic gene structure. Molecular microbiology, 29(1), 97–110
Christiansen, G., Jensen, L. T., Boesen, T., Emmersen, J., Ladefoged, S. A., Schiøtz, L. K., & Birkelund, S. (1997). Molecular biology of Mycoplasma. Wiener klinische Wochenschrift, 109(14-15), 557–561
Ladefoged, S. A., Jensen, L. T., Brock, B., Birkelund, S., & Christiansen, G. (1996). Analysis of 0.5-kilobase-pair repeats in the Mycoplasma hominis lmp gene system and identification of gene products. Journal of bacteriology, 178(10), 2775–2784
Jensen, L. T., Ladefoged, S., Birkelund, S., & Christiansen, G. (1995). Selection of Mycoplasma hominis PG21 deletion mutants by cultivation in the presence of monoclonal antibody 552. Infection and immunity, 63(9), 3336–3347
Ladefoged, S. A., Birkelund, S., Hauge, S., Brock, B., Jensen, L. T., & Christiansen, G. (1995). A 135-kilodalton surface antigen of Mycoplasma hominis PG21 contains multiple directly repeated sequences. Infection and immunity, 63(1), 212–223