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Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis
Max Kaufmann, Hayley Evans, Anna-Lena Schaupp, Jan Broder Engler, Gurman Kaur, Anne Willing, Nina Kursawe, Charlotte Schubert, Kathrine E. Attfield, Lars Fugger and Manuel A. Friese (2021)
Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases
Lars Fugger, Lise Torp Jensen, Jamie Rossjohn (2020)
Identifying Cross-Disease Components of Genetic Risk Across Hospital Data in the UK Biobank
Cortes A, Albers PK, Dendrou CA, Fugger L, McVean G. (2020)
B Cell Tolerance and Antibody Production to the Celiac Disease Autoantigen Transglutaminase 2
Fleur du Pre M, Blazevski J, Dewan A, Stamnaes J, Kanduri C, Sandve G, Johannesen M, Lindstad C, Hnida K, Fugger L, Melino G, Qiao SW, Sollid LM. Journal of Experimental Medicine (2020)
A Plasmid-Encoded Peptide From Staphylococcus Aureus Induces Anti-Myeloperoxidase Nephritogenic Autoimmunity
Ooi, J D, Jiang J, Eggenhuizen P, Ling L, Timmeren M, Loh K, O'Sullivan K, Gan P, Zhong Y, Tsyganov K, Shochet L, Ryan J, Stegeman C, Fugger L, Reid H, Rossjohn J, Heeringa P, Holdsworth S, Peleg A, Kitching R. (2019) Nature Communications
HLA variation and disease
Dendrou CA, Petersen J, Rossjohn J, Fugger L. (2018) Nature Reviews Immunology
Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank
Cortes A, Dendrou CA, Motyer A, Jostins, Vukcevic D, Dilthey A, Donnelly P, Leslie S, Fugger L, McVean G. (2017) Nature Genetics
Structural and regulatory diversity shape HLA-C protein expression levels.
Kaur G, Gras S, Mobbs JI, Vivian JP, Cortes A, Barber T, Kuttikkatte SB, Jensen LT, Attfield KE, Dendrou CA, Carrington M, McVean G, Purcell AW, Rossjohn J, Fugger L. (2017) Nature Communications
Neuroinflammation - using big data to inform clinical practice
Dendrou CA, McVean G, Fugger L. (2016) Nature Reviews Neurology
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Dendrou CA, Cortes A, Shipman L, Evans HG, Attfield KE, Jostins L, Barber T, Kaur G, Kuttikkatte SB, Leach OA, Desel C, Faergeman SL, Cheeseman J, Neville MJ, Sawcer S, Compston A, Johnson AR, Everett C, Bell JI, Karpe F, Ultsch M, Eigenbrot C, McVean G, Fugger L. (2016) Science Translational Medicine
Immunopathology of multiple sclerosis
Dendrou CA, Fugger L, Friese MA. (2015) Nature Reviews Immunology
Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis Friese, M. A., Schattling, B. and Fugger, L. (2014) Nature Reviews Neurology
Weighing in on autoimmune disease: Big data tip the scale
Dendrou, C. A., Bell, J. I. and Fugger, L. (2013) Nature Medicine
Genomewide association studies and common disease-realizing clinical utility
Fugger, L., McVean, G. and Bell, J. I. (2012) The New England Journal of Medicine
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
Gregory, A. P., Dendrou, C. A., et al., Fugger, L. (2012) Nature
From genes to function: The next challenge in the genetics of multiple sclerosis.
Fugger, L., Friese, M. and Bell, J. (2009) Nature Reviews Immunology
A mechanism for T-cell-mediated autoimmune disease resulting from highly specific but low affinity cross-reactivity to common microbial peptides.
Harkiolaki, M., Holmes, S., et al., Fugger, L. (2009) Immunity
Opposing effects of HLA class I molecules in tuning autoreactive CD8+T-cells in multiple sclerosis.
Friese, M., Jakobsen, K., et al., Fugger, L. (2008) Nature Medicine
Interleukin-17 production in CNS-infiltrating T-cells and glial cells is associated with active disease in multiple sclerosis.
Tzartos, J., Friese, M., et al. Fugger, L. (2008) Am. J. Pathology
Acid-sensing ion channel 1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system.
Friese, M., Craner, M., et al., Fugger, L. (2007) Nature Medicine
Functional epistasis on a common MHC haplotype associated with multiple sclerosis.
Gregersen, J. W., Kranc, K., et al., Fugger L. (2006) Nature
MHC class II proteins and disease: a structural perspective.
Jones, E.Y.*, Fugger, L.*, Strominger, J.L., et al., (2006)
Nature Reviews Immunology, *Shared senior authorship.
A functional and structural basis for T cell receptor cross-reactivity in multiple sclerosis.
Lang, H., Jacobsen, H., et al., Fugger, L. (2002) Nature Immunology
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