Dr Max Kaufmann Clinical Research Fellow

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As a strong believer in the transformational power of digitalisation, Max Kaufmann investigates molecular disease mechanisms of multiple sclerosis using a high-throughput, data-driven approach. By treating patients as a physician at the University Medical Centre Hamburg-Eppendorf (Germany) and observing the current limitations of available medicines first-hand, he draws great motivation to extend beyond these boundaries with his research. Dr. Kaufmann’s work with the Fugger group began in 2018 with a joint project unravelling the role of CNS-colonizing immune cells in the progression of multiple sclerosis through single cell RNA-sequencing. In 2021 he moved to Oxford with his family to extend and intensify the collaboration with the Oxford Centre of Neuroinflammation as a visiting postdoc. In continuation of this stay he now works remotely from Hamburg on the data analysis side of the lab.

Kaufmann M, Evans H, Schaupp A-L, Engler J B, Kaur G, Willing A, Kursawe N, Schubert C, Attfield K E, Fugger L and Friese M A 2021 Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis Med 2 296-312.e8. 2021. doi: https://doi.org/10.1016/j.medj.2021.01.006

 

Poch T, Krause J, Casar C, Liwinski T, Glau L, Kaufmann M, Ahrenstorf AE, Hess LU, Ziegler AE, Martrus G, Lunemann S, Sebode M, Li J, Schwinge D, Krebs CF, Franke A, Friese MA, Oldhafer KJ, Fischer L, Altfeld M, Lohse AW, Huber S, Tolosa E, Gagliani N, Schramm C. Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis. J Hepatol 2021. doi: https://doi.org/10.1016/j.jhep.2021.03.016

 

Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH. Neuronal vulnerability and multilineage diversity in multiple sclerosis. Nature 573, 75–82. 2019. https://doi.org/10.1038/s41586-019-1404-z

 

Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, Thomas U, Bose A, Bauer S, Träger S, Miller KK, Brück W, Duncan KE, Salinas G, Soba P, Gundelfinger ED, Merkler D, Friese MA. Bassoon proteinopathy drives neurodegeneration in multiple sclerosis. Nat Neurosci. 22, 887–896. 2019. doi: https://doi.org/10.1038/s41593-019-0385-4

 

Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The S-MML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ. Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life. Immunity 50, 462-476.e8. 2019. doi: https://doi.org/10.1016/j.immuni.2018.12.010

 

Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs K-W, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger K-P, Leypoldt F, German Network for Research on Autoimmune Encephalitis (GENERATE). Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis. Ann Neurol. 83, 863–869. 2018. doi: https://doi.org/10.1002/ana.25216

 

Kaufmann M, Feijs KLH, Lüscher B,. Function and regulation of the mono-ADP-ribosyltransferase ARTD10. Curr Top Microbiol Immunol. 384, 167–88. 2015. doi: https://doi.org/10.1007/82_2014_379